Aryloxy Acetic Acid Diuretics with Uricosuric Activity. I. Polycyclic Aryloxy Acetic Acids

Masayuki KITAGAWA; Tetsuya MIMURA; Makoto TANAKA

doi:10.1248/cpb.39.2400

著者情報

キーワード: aryloxy acetic acid, 2, 3-dihydro-1-oxo-1H-isoindole, 3, 4-dihydro-4-oxo-3H-quinazoline, 4-oxo-4H-1-benzopyran, xanthone, benzo[b]furan, indene, ((5-chloro-4-oxo-3-phenyl-4H-1-benzopyran-7-yl)oxy)acetic acid, diuretic, uricosuric, anti-hypertensive activity

ジャーナルフリー

1991 年 39 巻 9 号 p. 2400-2407

DOI https://doi.org/10.1248/cpb.39.2400

詳細

抄録

In order to obtain lead compounds for uricosuric diuretics, various polycyclic aryloxy acetic acids [isoindole derivative (7), quinazoline derivative (15), benzopyran derivative (20), xanthone derivative (24), benzofuran derivative (30) and indene derivative (36)] were prepared. These compounds were evaluated for diuretic activity in rats, uricosuric activity in rats and antihypertensive activity in 11-deoxycorticosterone acetate (DOCA)/salt hypertensive rats. Among the compounds, 20 showed potent diuretic, uricosuric and moderate antihypertensive activities. Therefore, we selected 20 as a lead compound for development of new uricosuric diuretics.

責任著者(Corresponding author)

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