ISOLATION OF A NEW ANTITUMOR SUBSTANCE FROM BACILLUS STEAROTHERMOPHILUS

Yasuhiro KOHAMA; Tetsuyuki TERAMOTO; Kentaro IIDA; Norihito MURAYAMA; Taro SAMBA; Noriko TATEBATAKE; Yuzo KAYAMORI; Kazutake TSUJIKAWA; Tsutomu MIMURA

doi:10.1248/cpb.39.2468

小濱靖弘, 寺本哲之, 飯田健太郎, 村山宣人, 仙波太郎, 立畠典子, 栢森裕三, 辻川和丈, 三村務

著者情報

キーワード: Bacillus stearothermophilus, thermophile, antitumor substance, P388-D1, P-815

ジャーナルフリー

1991 年 39 巻 9 号 p. 2468-2470

DOI https://doi.org/10.1248/cpb.39.2468

詳細

抄録

A new antitumor substance, BS-1, was isolated from the autolysate and culture filtrate of Bacillus stearothermophilus UK563 by ethylacetate extraction and HPLC. BS-1 inhibited the proliferation of mouse macrophage-like cells, P388-DI (IC₅₀ : 4μg/ml) and mouse mastocytoma, P-815 (IC₅₀ : 0.6μg/ml), but not that of Balb/c 3T3.

責任著者(Corresponding author)

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