抄録
The structure and antitumor activity of Smith-type digradation products (OL-2-I, OL-2-II and OL-2-III) of an alkali-soluble glucan, OL-2, isolated from a crude fungal drug "Leiwan" (Omphalia lapidescens) were investigated.Methylation analysis suggested that OL-2-I was a (1→3)-β-D-glucan with approximately one branch at every three main chain glucosyl units at each C-6 position; OL-2-II was a (1→3)-β-D-glucan with approximately one branch at two main chain glucosyl units at each C-6 position, and OL-2-III was a (1→3)-β-D-glucan with approximately one branch at twenty four main chain glucosyl units at each C-6 position (number of all main chain glucosyl units is on average). OL-2-I, OL-2-II and OL-2-III whic were Smith-type digradation products of OL-2, showed potent antitumor activity against the solid form of sarcoma 180 in ICR mice. These results indicated that the degree of β-linked branching at position 6 was remarkably related to the atitumor activity.
