A NOVEL HOMOISOCARBACYCLIN ANALOG WITH POTENT AND LONG-LASTING ACTIVITY

Masakatsu SHIBASAKI; Atsuo TAKAHASHI; Tsuyoshi AOKI; Hiroyasu SATO; Shin-ichi YAMADA; Michiko KUDO; Kentaro KOGI; Sen-ichi NARITA

doi:10.1248/cpb.40.279

Masakatsu SHIBASAKI, Atsuo TAKAHASHI, Tsuyoshi AOKI, Hiroyasu SATO, Shin-ichi YAMADA, Michiko KUDO, Kentaro KOGI, Sen-ichi NARITA

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Keywords: isocarbacyclin analog, homoisocarbacyclin analog, TY-11223, prostacyclin, iloprost, platelet antiaggregation activity, hypotensive effect

JOURNAL FREE ACCESS

1992 Volume 40 Issue 1 Pages 279-281

DOI https://doi.org/10.1248/cpb.40.279

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Abstract

A synthesis of a novel and chemically stable homoisocarbacyclin analog, TY-11223 (3___-), has been accomplished.The analog (3___-), given intravenously or orally, showed potent and long-lasting activities in inhibiting platelet aggregation and, in addition, a good selectivity in biological activities.

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