SYNTHESIS OF (1R, 2R, 4S, 17R)-LOBA-8, 10, 13(15)-TRIENE-17, 18-DIOL, A MARINE DITERPENE

Hiroto NAGAOKA; Makoto IWASHIMA; Masayoshi MIYAHARA; Yasuji YAMADA

doi:10.1248/cpb.40.556

Chemical and Pharmaceutical Bulletin

Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363

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Volume 40 (1992) Issue 2
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SYNTHESIS OF (1R, 2R, 4S, 17R)-LOBA-8, 10, 13(15)-TRIENE-17, 18-DIOL, A MARINE DITERPENE

Hiroto NAGAOKA, Makoto IWASHIMA, Masayoshi MIYAHARA, Yasuji YAMADA

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Keywords: total synthesis, marine diterpene, (1R, 2R, 4S, 17R)-loba-8, 10, 13(15)-triene-17, 18-diol, prenylated elemane skeleton

JOURNAL FREE ACCESS

1992 Volume 40 Issue 2 Pages 556-558

DOI https://doi.org/10.1248/cpb.40.556

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Abstract

Synthesis of marine diterpene 1 (1R, 2R, 4S, 17R) has been achieved via coupling of ketone 7 and sulfone 6, leading to the determination of hte absolute stereochemistry.

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