Triazole Antifungals. V. Synthesis and Antifungal Activities of Some Amides Related to 3-Acylamino-2-aryl-1-triazolyl-2-butanol

Teruo TANAKA; Noriko TAKEDA; Toshiyuki KONOSU; Hiroshi YASUDA; Sadao OIDA

doi:10.1248/cpb.40.661

Teruo TANAKA, Noriko TAKEDA, Toshiyuki KONOSU, Hiroshi YASUDA, Sadao OIDA

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Keywords: antifungal activity, 1, 2, 4-triazole, 3-carbamoyl-2-aryl-1-(triazol-1-yl)-2-butanol, 4-acylamino-2-aryl-3-methyl-1-(triazol-1-yl)-2-butanol, structure-activity relationship, β-lactone, stereochemistry assignment

JOURNAL FREE ACCESS

1992 Volume 40 Issue 3 Pages 661-665

DOI https://doi.org/10.1248/cpb.40.661

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Abstract

Amides, 2 and 3, related to the potent antifungal triazole-amide 3-acylamino-2-aryl-1-triazolyl-2-butanol (1) were synthesized starting from the triazole-alcohol 6. The antifungal activity of 2 and 3 aganist a mouse systemic Candida albicans infection was found to be less potent than that of 1.

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