Homeostasis as Regulated by Activated Macrophage. V. Suppression of Diabetes Mellitus in Non-obese Diabetic Mice by LPSw (a Lipopolysaccharide from Wheat Flour)

Makoto IGUCHI; Hiroyuki INAGAWA; Takashi NISHIZAWA; Takafumi OKUTOMI; Akinobu MORIKAWA; Gen-Ichiro SOMA; Den'ichi MIZUNO

doi:10.1248/cpb.40.1004

Makoto IGUCHI, Hiroyuki INAGAWA, Takashi NISHIZAWA, Takafumi OKUTOMI, Akinobu MORIKAWA, Gen-Ichiro SOMA, Den'ichi MIZUNO

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Keywords: diabetes, non-obese diabetic mice, lipopolysaccharide, macrophage, homeostasis

JOURNAL FREE ACCESS

1992 Volume 40 Issue 4 Pages 1004-1006

DOI https://doi.org/10.1248/cpb.40.1004

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Abstract

A lipopolysaccharide from wheat flour (LPSw) which was isolated and characterized is shown to exert definitely a suppressive effect on incidence of type 1 diabetes in mice. Therapeutic effect on type 2 diabetes in patients was also obtained, though only from preliminaly results. The percutaneous route of administration is most favorable. The important role that precursor tumor necrosis factor, free or cell bound, may play in this mechanism is discussed.

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