Cytotoxic Quassinoids and Tirucallane-Type Triterpenes from the Woods of Eurycoma longifolia

Abstract

New cytostatic quassinoids, 6α-hydroxyeurycomalactone (1), longilactone (2) and 14, 15β-dihydroxyklaineanone (3) were isolated from the woods of Eurycoma longifolia (Simaroubaceae) with three cytotoxic quassinoids, 11-dehydroklaineanone (4), eurycomalactone (5) and 5, 6-dehydroeurycomalactone (6), and with seven cytotoxic tirucallane-type triterpenes, niloticin (7), dihydroniloticin (8), piscidinol A (9), bourjotinolone A (10), 3-episapelin A (11), melianone (12) and hispidone (13). All of them showed potent cytotoxic activity against P388 and KB cells.