Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
Cytotoxic Quassinoids and Tirucallane-Type Triterpenes from the Woods of Eurycoma longifolia
Hideji ITOKAWAEtsuko KISHIHiroshi MORITAKoichi TAKEYA
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1992 Volume 40 Issue 4 Pages 1053-1055

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Abstract

New cytostatic quassinoids, 6α-hydroxyeurycomalactone (1), longilactone (2) and 14, 15β-dihydroxyklaineanone (3) were isolated from the woods of Eurycoma longifolia (Simaroubaceae) with three cytotoxic quassinoids, 11-dehydroklaineanone (4), eurycomalactone (5) and 5, 6-dehydroeurycomalactone (6), and with seven cytotoxic tirucallane-type triterpenes, niloticin (7), dihydroniloticin (8), piscidinol A (9), bourjotinolone A (10), 3-episapelin A (11), melianone (12) and hispidone (13). All of them showed potent cytotoxic activity against P388 and KB cells.

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