LIPASE-CATALYZED ENANTIOSELECTIVE HYDROLYSIS OF 4-ALKYL-1, 4-DIHYDROPYRIDINE DERIVATIVES : SYNTHESIS OF (+)- AND (-)-METHYL 2-(PHENYLTHIO)ETHYL 1, 4-DIHYDRO-2, 4, 6-TRIMETHYL-3, 5-PYRIDINEDICARBOXYLATE (PCA 4248)

Abstract

Asymmetric synthesis of (+)- and (-)-PCA 4248 (PAF antagonist) was achieved using lipase-catalyzed enantioselective hydrolysis of the acyloxymethyl esters. The enzymatic reaction proceeded under the mild conditions in an organic solvent.