Abstract
Mequitazine (Meq; 10-(3-quinuclidinylmethyl)phenothiazine) disolved in water formed a complex with polyvinylpyrrolidone (PVP) due to hydrophobic interaction and with sodium alginate (NaAlg) by virtue of ion-dipole and/or -ion interaction between carboxylate groups and quinuclidinyl groups. The binding ratio of Meq to NaAlg was higher than that to PVP, while the adsorption amount of PVP by solid Meq was higher than that of NaAlg. It was shown by electrophoresis that a positive charge of Meq particles was reversed to a negative one after the adsorption of alginate. The degree of crystallinity of Meq recrystallized from an aqueous solution of these polymers was examined by an X-ray powder diffractometry. It decreased with polymer concentration owing to the complex formation and adsorption onto its crystal nuclei and/or embryos.
