Isolation and Structures of Antibacterial Binaphtho-α-pyrones, Talaroderxines A and B, from Talaromyces derxii

Kazumi SUZUKI; Koohei NOZAWA; Shoichi NAKAJIMA; Shun-ichi UDAGAWA; Ken-ichi KAWAI

doi:10.1248/cpb.40.1116

Kazumi SUZUKI, Koohei NOZAWA, Shoichi NAKAJIMA, Shun-ichi UDAGAWA, Ken-ichi KAWAI

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Keywords: Talaromyces derxii, 6, 6'-binaphtho-α-pyrone, talaroderxine A, talaroderxine B, viriditoxin, atropisomer, antibacterial activity

JOURNAL FREE ACCESS

1992 Volume 40 Issue 5 Pages 1116-1119

DOI https://doi.org/10.1248/cpb.40.1116

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Abstract

New compounds designated talaroderxines A (1) and B (2) were isolated from a new heterothallic ascomycetous fungus, Talaromyces derxii, cultivated on rice. The structures of 1a and 1b were elucidated by means of spectroscopic examination and chemical reactions. Talaroderxines A (1a) and B (1b) are atropisomers of a 6, 6'-binaphtho-α-pyrone derivative, and have strong antibacterial activity against Bacillus subtilis.

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