Selected Ion Monitoring for the Determination of Bromovalerylurea in Human Plasma

Jun KOKATSU; Rie YOMODA; Toshio SUWA

doi:10.1248/cpb.40.1517

著者情報

キーワード: bromovalerylurea, solvent extraction, gas chromatography-selected ion monitoring, chemical ionization, human plasma, oral administration

ジャーナルフリー

1992 年 40 巻 6 号 p. 1517-1519

DOI https://doi.org/10.1248/cpb.40.1517

詳細

抄録

A gas chromatography-selected ion monitoring procedure with chemical ionization is described for the determination of bromovalerylurea (BVU) in human plasma. BVU was extracted with ether after addition of 2-bromo-2-methylpropylurea as an internal standard. The lower limit of BVD quantification by this method was 2ng/0.1ml plasma volume. This procedure was used to determine the sequential plasma levels of BVU in a human volunteer following a single oral dose of a commercial analgesic.

責任著者(Corresponding author)

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