Synthesis, Structure and Antitumor of a Water-Soluble Platinum Complex, (1R, 3R, 4R, 5R)-(-)-Quinato(1R, 2R-cyclohexanediamine)platinum(II)

Abstract

The reaction of dihydroxo(1R, 2R-cyclohexanediamine)platinum(II) with (-)-quinic acid gave a water soluble complex, (-)-quinato(1R, 2R-cyclohexanediamine)platinum(II). The crystal structure of the complex was determined by X-ray analysis. The data indicate a chelation of the α-hydroxycarboxylic acid part of quinic acid to platinum(II).The complex shows moderate antitumor activity against murine leukemia L1210 at high doses (T/C×100=179% at a dose of 200mg/kg).