Synthetic Studies on Naturally Occurring Coumarins. I. A Convenient Synthesis of 5, 8-Dimethoxy- and 7, 8-Dimethoxycoumarins

Hisashi ISHII; Kazuhiro KENMOTSU; Werner DOPKE; Takashi HARAYAMA

doi:10.1248/cpb.40.1770

Hisashi ISHII, Kazuhiro KENMOTSU, Werner DOPKE, Takashi HARAYAMA

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Keywords: coumarin synthesis, 5, 8-dimethoxycoumarin, 7, 8-dimethoxycoumarin, structure revision, Artemisia cavifolia, dimethoxysalicylaldehyde, Wittig reagent

JOURNAL FREE ACCESS

1992 Volume 40 Issue 7 Pages 1770-1772

DOI https://doi.org/10.1248/cpb.40.1770

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Abstract

The coumarin isolated from Ariemisia carvifolia WALL was proved synthetically to be 7, 8-dimethoxycoumarin and not 5, 8-dimethoxycoumarin as previously proposed. 3, 4-Dimethoxy- and 3, 6-dimethoxysalicylaldehydes gave the corresponding coumarins in good yield by the method using phosphorane reagent in N, N-diethylaniline under reflux.

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