Synthesis and Antiarrhythmic Activity of 2, 2-Dialkyl-1'-(N-substituted aminoalkyl)-spiro-[chroman-4, 4'-imidazolidine]-2', 5'-diones

Masayuki MATSUKURA; Yoshiharu DAIKU; Kouichirou UEDA; Satoru TANAKA; Toshiji IGARASHI; Norio MINAMI

doi:10.1248/cpb.40.1823

Masayuki MATSUKURA, Yoshiharu DAIKU, Kouichirou UEDA, Satoru TANAKA, Toshiji IGARASHI, Norio MINAMI

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Keywords: antiarrhythmic activity, 2, 2-dialkyl-1'-(N-substituted aminoalkyl)-spiro-[chroman-4, 4'-imidazolidine]-2', 5'-dione, chloroform-induced arrhythmia, acontitine-induced arrhythmia, (-)-6-chloro-2, 2-dimethyl-1'-[3-(4-hydroxypiperidino)propyl]-spiro-[chroman-4, 4'-imidazolidine]-2', 5'-dione, spirohydantoin

JOURNAL FREE ACCESS

1992 Volume 40 Issue 7 Pages 1823-1827

DOI https://doi.org/10.1248/cpb.40.1823

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Abstract

A novel series of 2, 2-dialkyl-1'-(N-substituted aminoalkyl)-spiro-[chroman-4, 4'-imidazolidine]-2', 5'-diones was synthesized and evaluated for antiarrhythmic activity in chloroform- or/and aconitine-induced ventricular arrhythmia in mice. Among these compounds, (-)-6-chloro-2, 2-dimethyl-1'-[3-(4-hydroxypiperidino)propyl]-spiro-[chroman-4, 4'-imidazolidine]-2', 5'-dione was found to be more effective than reference agents and was selected for further development.

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