1992 Volume 40 Issue 7 Pages 1925-1927
(3R, 4R, 5R)-1-(tert-Butoxycarbonyl)-3, 4-isopropylidenedioxy-5-methoxymethyl-2-pyrrolidinone (6), a useful chiral intermediate for the preparation of calyculins, was synthesized starting from (S)-pyroglutaminol via the O-methylation of 1c with diazomethane in the presence of fluoboric acid and cis-dihydroxylation of the α, β-unsaturated lactam (4) as the key reactions.