Synthetic Study on 1, 3-Polyols. Stereoselective Synthesis of Four Diastereoisomers of 1, 2, 4, 6, 8-Pentol Derivatives

Yuji MORI; Yasunori KOHCHI; Makoto SUZUKI; Hiroshi FURUKAWA

doi:10.1248/cpb.40.1934

Yuji MORI, Yasunori KOHCHI, Makoto SUZUKI, Hiroshi FURUKAWA

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Keywords: 1, 3-polyol synthesis, 1, 3-diastereoselective reduction, octane-1, 2, 4, 6, 8-pentol derivative, 1, 2, 4, 6-tetrabenzoyloxy-7-octene, lithium aluminum hydride, diethylmethoxyborane, tetramethylammonium triacetoxyborohydride

JOURNAL FREE ACCESS

1992 Volume 40 Issue 7 Pages 1934-1936

DOI https://doi.org/10.1248/cpb.40.1934

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Abstract

The stereoselective synthesis of four diastereoisomers of octane-1, 2, 4, 6, 8-pentol derivatives is described by means of a convergent 1, 3-polyol synthesis using a four-carbon unit, where 1, 3-syn- and anti-selective reductions have been effectively employed.

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