Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
Inhibitors of Prostaglandin Biosynthesis from Dalbergia odorifera
Yukihiro GODAFumiyuki KIUCHIMasaaki SHIBUYAUshio SANKAWA
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1992 Volume 40 Issue 9 Pages 2452-2457

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Abstract

he root heartwood of Dalbergia odorifera T. CHEN (Leguminosae) is a Chicese medicinal drug (Japanese name koshinko) used for a stagnant blood syndrome (stagnation of disordered blood; Japanese, oketsu). In addition to 10 known compounds, five new phenolic compounds, isomucronustyrene and hydroxyobtustyrene (cinnamylphenols), (+)-isoduartin (isoflavan), odoriflavene (isoflav-3-ene) and (-)-odoricarpan (pterocarpan) were isolated and their structures were elucidated on the basis of chemical and spectroscopic methods. Of the fifteen compounds isolated, cinnamylphenols, isoflavans, isoflavene and benzoic acid derivative significantly inhibited prostaglandin biosynthesis as well as platelet aggregation induced by arachidonic acid.

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