Photoaffinity Labeling of the Electroplax Sodium Channel with a Photoreactive μ-Conotoxin Carrying a Radioactive and Chromogenic Diazirine

Yasumaru HATANAKA; Hitoshi NAKAYAMA; Yuichi KANAOKA

doi:10.1248/cpb.40.2537

畑中保丸, 中山仁, 金岡祐一

著者情報

キーワード: photoaffinity labeling, μ-contoxin, peptide toxin, sodium channel, radioisotope labeling, diazirine, carbene

ジャーナルフリー

1992 年 40 巻 9 号 p. 2537-2539

DOI https://doi.org/10.1248/cpb.40.2537

詳細

抄録

Photoreactive derivatives of μ-conotoxin GIIIA carrying a radioactive and chromogenic diazirine have been prepared as a photoaffinity labeling reagent for muscle-type sodium channels. When the reagent was photolyzed in the presence of the eel sodium channel, radioactivity was specifically incorporated into the channel protein.

責任著者(Corresponding author)

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