Synthesis and Antihypertensive Activities of New 1, 4-Dihydropyridine Derivatives Containing a Nitrooxy Moiety at the 3-Ester Position

Abstract

The synthesis of a new series of dihydropyridines containing a nitrooxy mojety at the 3-ester position is described.The antihypertensive activity of the compounds was examined and compared with that of nifedipine; some of them were relatively potent. The structure-activity relationship is also discussed.