Structural Characteristics of Lipid-Lipase Aggregates for Enantioselective Hydrolysis in Organic Solvents

Hiroyuki AKITA; Isao UMEZAWA; Ikuko SAKURAI; Takeshi OISHI

doi:10.1248/cpb.41.12

Hiroyuki AKITA, Isao UMEZAWA, Ikuko SAKURAI, Takeshi OISHI

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Keywords: enantioselective hydrolysis, α-acyloxy ester, lipid-lipase aggregate, diltiazem hydrochloride, X-ray diffraction

JOURNAL FREE ACCESS

1993 Volume 41 Issue 1 Pages 12-15

DOI https://doi.org/10.1248/cpb.41.12

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Abstract

An ether-linked lipid-lipase aggregate was found to function as an immobilized biocatalyst. Three kinds of aggregate, I, III, and IV, obtained by sonication treatment were considered to have stacked bilayer structure of the lipid in the crystalline phase based on X-ray diffraction analysis. On the other hand, aggregate II obtained by the stirring method appeared to have an inverted micellar structure.

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