VICARIOUS NUCLEOPHILIC SUBSTITUTION OF PYRIDINES VIA THEIR DICYANOMETHYLIDE DERIVATIVES

Takashi ITOH; Kazuhiro NAGATA; Mamiko OKADA; Akio OHSAWA

doi:10.1248/cpb.41.220

Takashi ITOH, Kazuhiro NAGATA, Mamiko OKADA, Akio OHSAWA

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Keywords: pyridine, pyridinium dicyanomethylide, vicarious nucleophilic substitution, tetracyanoethylene oxide, 1-chloromethyl phenyl sulfone

JOURNAL FREE ACCESS

1993 Volume 41 Issue 1 Pages 220-222

DOI https://doi.org/10.1248/cpb.41.220

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Abstract

Vicarious nucleophilic substitution of pyridinium 1-dicyanomethylides with 1-chloromethyl phenyl sulfone gave corresponding 4-substituted derivatives. The dicyanomethylene group was readily eliminated via radical reaction to afford 4-phenylsulfonylmethylpyridines.

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