Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Electrochemical Oxidation of Anti-tumor Agent, Etoposide
Rika OBATA, Takeshi OHNUMA
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Keywords: etoposide, anti-tumor agent, dehydroetoposide, electrochemical oxidation, controlled potential
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1993 Volume 41 Issue 10 Pages 1846-1847

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Abstract
As part of a search for new potent derivatives, electrochemical oxidation of etoposide (1) was carried out under controlled potential (500mV) to yield 1, 2-dehydroetoposide (4), 4'-O-demethyl-1, 2, 3, 4-tetradehydro-4-dehydroxy-podophyllotoxin (5) and 1, 2, 3, 4-tetradehydroetoposide (6). They showed no cytotoxicity against B16-melanoma.
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© The Pharmaceutical Society of Japan
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