Abstract
Two new withanolides, physapruins A and B, were isolated from the methanolic extract of the fresh aerial parts of Physalis pruinosa (Solanaceae), and their structures have been determined to be 4β, 14α, 17β, 20β-tetrahydroxy-1-oxo-20S, 22R-witha-2, 5, 24-trienolide (1) and 6β-acetoxy-5α-butoxy-14α-17β-20β-trihydroxy-1-oxo-20S, 22R-witha-2, 24-dienolide (2) on the basis of spectral evidence.
