Fungal Metabolites. IX. Synthesis of a Membrane-Modifying Peptide, Hypelcin A-III, from Hypocrea peltata

Kouji MATSUURA; Akgul YESILADA; Akira IIDA; Yasuo NAGAOKA; Yoshihisa TAKAISHI; Tetsuro FUJITA

doi:10.1248/cpb.41.1955

Kouji MATSUURA, Akgul YESILADA, Akira IIDA, Yasuo NAGAOKA, Yoshihisa TAKAISHI, Tetsuro FUJITA

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Keywords: Hypocrea peltata, peptaibol, hypelcin, α-aminoisobutyric acid, isovaline

JOURNAL FREE ACCESS

1993 Volume 41 Issue 11 Pages 1955-1959

DOI https://doi.org/10.1248/cpb.41.1955

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Abstract

A membrane-modifying peptide antibiotic having uncoupling activity on rat liver mitochondria, hypelcin A-III, has been synthesized by assembling five peptide fragments via the N, N'-dicyclohexylcarbodiimide method. The synthesized hypelcin A-III was identical with the natural product.

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