Author's Organization：School of Pharmaceutical Sciences, University of Shizuoka School of Pharmaceutical Sciences, University of Shizuoka School of Pharmaceutical Sciences, University of Shizuoka
Optically active lipopeptide derivatives have been synthesized by the use of chiral glycerol derivatives. Lipopeptide WS1279 derivatives with (R)-glycerol moieties showed a higher mitogenic activity than those with the (S)-configuration. Various N-protected lipopeptide and N-deprotected derivatives showed increased mitogenic activity.
