ELATOSIDES A AND B, POTENT INHIBITORS OF ETHANOL ABSORPTION IN RATS FROM THE BARK OF ARALIA ELATA SEEM : THE STRUCTURE-ACTIVITY RELATIONSHIPS OF OLEANOLIC ACID OLIGOGLYCOSIDES

Masayuki YOSHIKAWA; Emiko HARADA; Hisashi MATSUDA; Toshiyuki MURAKAMI; Johji YAMAHARA; Nobutoshi MURAKAMI

doi:10.1248/cpb.41.2069

Masayuki YOSHIKAWA, Emiko HARADA, Hisashi MATSUDA, Toshiyuki MURAKAMI, Johji YAMAHARA, Nobutoshi MURAKAMI

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Keywords: ethanol absorption inhibitory effect, structure-activity relationship, oleanolic acid oligoglycoside, elatoside A, elatoside B, Aralia elata

JOURNAL FREE ACCESS

1993 Volume 41 Issue 11 Pages 2069-2071

DOI https://doi.org/10.1248/cpb.41.2069

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Abstract

By monitoring the inhibitory effect on ethanol absorption in rats, new active saponins named elatosides A and B were isolated from the bark of Aralia elata SEEM. together with elatosides C and D. The structures of elatosides A, B, C, and D were elucidated on the basis of chemical and physicochemical evidence. The inhibitory effects of several oleanolic acid oligoglycosides on ethanol absorption have been examined and some structure-activity relationships have been found.

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