ELATOSIDES A AND B, POTENT INHIBITORS OF ETHANOL ABSORPTION IN RATS FROM THE BARK OF ARALIA ELATA SEEM : THE STRUCTURE-ACTIVITY RELATIONSHIPS OF OLEANOLIC ACID OLIGOGLYCOSIDES

Masayuki YOSHIKAWA; Emiko HARADA; Hisashi MATSUDA; Toshiyuki MURAKAMI; Johji YAMAHARA; Nobutoshi MURAKAMI

doi:10.1248/cpb.41.2069

吉川雅之, 原田英美子, 松田久司, 村上敏之, 山原條二, 村上啓寿

著者情報

キーワード: ethanol absorption inhibitory effect, structure-activity relationship, oleanolic acid oligoglycoside, elatoside A, elatoside B, Aralia elata

ジャーナルフリー

1993 年 41 巻 11 号 p. 2069-2071

DOI https://doi.org/10.1248/cpb.41.2069

詳細

抄録

By monitoring the inhibitory effect on ethanol absorption in rats, new active saponins named elatosides A and B were isolated from the bark of Aralia elata SEEM. together with elatosides C and D. The structures of elatosides A, B, C, and D were elucidated on the basis of chemical and physicochemical evidence. The inhibitory effects of several oleanolic acid oligoglycosides on ethanol absorption have been examined and some structure-activity relationships have been found.

責任著者(Corresponding author)

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