Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Screening of Plant Constituents for Effect on Glucose Transport Activity in Ehrlich Ascites Tumour Cells
村上 千景明賀 圭子笠井 良次大谷 和弘黒川 知則石橋 貞彦/山崎 和男Kazuo YAMASAKI
ジャーナル フリー

1993 年 41 巻 12 号 p. 2129-2131


The effect of plant extracts on D-glucose uptake by Ehrlich ascites tumour cells was examined. Among the 23 exracts of medicinal plants, five samples inhibited, and six samples activated, the uptake significantly. From one of the active plants, Lagerstroemia speciosa, two triterpenoids, colosolic acid and maslinic acid were isolated. Colosolic acid was shown to be a glucose transport activator. Scince this compound was known to have hypoglycemic activity, our simple in vitro bioassay method can at least be used as a first screening for anti-diabetic activity.

© The Pharmaceutical Society of Japan
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