Lipophilicity and Chromatographic Behaviour of Benzoic Acid Derivatives

Abstract

The Rm values of 32 compounds, derivatives of benzoic acid, were determined by reversed-phase thin layer chromatography (RP-TLC). The logarithm of the capacity factor, log k', of the same compounds was studied with reversed-phase high performance liquid chromatography (RP-HPLC). The lipophilicity was calculated according to the fragmental methods of Rekker and of Leo-Hansch and was compared with the experimental values of Rm and the log k'. The comparison shows that the Rekker method gives a better description of lipophilicity than that of the Leo-Hansch method.