A New Synthesis of the Aporphine Alkaloids (±)-Glaucine and(±)-Nantenine. Application of [3C + 3C] Annelation to the D-Ring Formation
1993 年 41 巻 3 号 p. 481-483
詳細
1993 年 41 巻 3 号 p. 481-483
A [3C + 3C] annelation using 1, 1-bis(ethulthio)-2-propanone was applied to a new synthesis of the aporphine alkaloids. Condensation of the ketone with the Mannich base gave two isomeric cyclohexenones, which were converted into the aporphine framework by aromatization. (±)-Glaucine and (±)-nantenine were prepared by employing this new aromatic synthesis.
