THE SYNTHESIS OF TRANS-3, 4-BIS-(3, 4-DIHYDROXYPHENYL)PYRROLIDINE, A NOVEL DA1 AGONIST

Tomonori HOSHIKO; Hiroki ISHIHARA; Mitsumasa SHINO; Nobuyuki MORI

doi:10.1248/cpb.41.633

THE SYNTHESIS OF TRANS-3, 4-BIS-(3, 4-DIHYDROXYPHENYL)PYRROLIDINE, A NOVEL DA₁ AGONIST

Tomonori HOSHIKO, Hiroki ISHIHARA, Mitsumasa SHINO, Nobuyuki MORI

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Keywords: dopamine, DA₁ agonist, trans-3, 4-bis-(3, 4-dihydroxyphenyl)pyrrolidine, Michael reaction, renal blood flow, mean arterial pressure

JOURNAL FREE ACCESS

1993 Volume 41 Issue 3 Pages 633-635

DOI https://doi.org/10.1248/cpb.41.633

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Abstract

The synthesis of trans-3, 4-bis-(3, 4-dihydroxyphenyl)pyrrolidine by the Michael reaction of esterenolate with nitro olefin is described. This compound was expected to be the agonist toward dopamine (DA₁) receptor with equipotent affinity and to be more selective than dopamine itself.

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