Synthesis of Naphtonaphthyridines by Skraup Reaction Using 3-Aminobenzo[g or h]quinoline

Isao TAKEUCHI; Yoshiki HAMADA; Minoru HIROTA

doi:10.1248/cpb.41.747

Chemical and Pharmaceutical Bulletin

Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363

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Volume 41 (1993) Issue 4
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Synthesis of Naphtonaphthyridines by Skraup Reaction Using 3-Aminobenzo[g or h]quinoline

Isao TAKEUCHI, Yoshiki HAMADA, Minoru HIROTA

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Keywords: Skraup reaction, cyclization, naphtho[2, 1-f][1, 7]naphthyridine, naphtho[2, 1-b][1, 5]naphthyridine, naphtho[2, 3-f][1, 7]naphthyridine, 4, 6-phenanthroline

JOURNAL FREE ACCESS

1993 Volume 41 Issue 4 Pages 747-751

DOI https://doi.org/10.1248/cpb.41.747

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Abstract

Naphtho[2, 1-f][1, 7]naphthyridine (5, angular type) and naphtho[2, 1-b][1, 5]naphthyridine (6, linear type) were obtained by the Skraup reaction of 3-aminobenzo[h]quinoline (4), but 3-aminobenzo[g]quinoline gave only naphtho-[2, 3-f][1, 7]naphthyridine (18, angular type).

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