Orally Active Cephalosporins. IV. Synthesis, Antibacterial Activity and Oral Absorption of 3-(1H-1, 2, 3-Triazol-4-yl)thiomethylthio-cephalosporins

Masaharu KUME; Tadatoshi KUBOTA; Yasuo KIMURA; Hiromu NAKASHIMIZU; Kiyoshi MOTOKAWA

doi:10.1248/cpb.41.758

Masaharu KUME, Tadatoshi KUBOTA, Yasuo KIMURA, Hiromu NAKASHIMIZU, Kiyoshi MOTOKAWA

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Keywords: cephalosporin, (1, 2, 3-triazol-4-yl)thiomethylthio group, synthesis, antibacterial activity, oral absorption, cefatrizine

JOURNAL FREE ACCESS

1993 Volume 41 Issue 4 Pages 758-762

DOI https://doi.org/10.1248/cpb.41.758

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Abstract

The synthesis, antibacterial activity and oral absorption of 3-(1H-1, 2, 3, -trazol-4-yl)thiomethylthio-3-cephem-4-carboxylic acids with various C-7 side chains (2) are described. The (1H-1, 2, 3-triazol-4-yl)thiomethylthio C-3 side chain was found to be an effective substituent for good oral absorption of cephalosporins with some C-7 side chains.

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