2'- AND 3'-SUBSTITUTED SANGIVAMYCINS : CONFORMATIONAL RESTRICTION BY THE GAUCHE EFFECT

Takamasa IIMORI; Yasushi MURAI; Yasuhiro WAKIZAWA; Yasuo OHTSUKA; Shokichi OHUCHI; Yoshio KODAMA; Takeshi OISHI

doi:10.1248/cpb.41.775

飯森隆昌, 村井安, 脇坂康尋, 大塚晏央, 大内章吉, 児玉佳男, 大石武

著者情報

キーワード: protein kinase C inhibitor, molecular design, conformational restriction, gauche effect, NMR analysis, NOE

ジャーナルフリー

1993 年 41 巻 4 号 p. 775-777

DOI https://doi.org/10.1248/cpb.41.775

詳細

抄録

Conformational restrictions of sangivamycin (1) could be achieved by the use of the gauche effect of the substitutents on the ribofranose moiety. The conformational deviations obtained by this method were found to nicely correlate with the inhibitory activity of PKC.

責任著者(Corresponding author)

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