Constituents of Cimicifugae Rhizoma. I. Isolation and Characterization of Ten New Cycloartenol Triterpenes from Cimicifuga heracleifolia KOMAROV

Jian Xin LI; Shigetoshi KADOTA; Masao HATTORI; Sadao YOSHIMACHI; Motoo SHIRO; Naoko OOGAMI; Hiroshi MIZUNO; Tsuneo NAMBA

doi:10.1248/cpb.41.832

Jian Xin LI, Shigetoshi KADOTA, Masao HATTORI, Sadao YOSHIMACHI, Motoo SHIRO, Naoko OOGAMI, Hiroshi MIZUNO, Tsuneo NAMBA

Author information

Jian Xin LI
Shigetoshi KADOTA
Masao HATTORI
Sadao YOSHIMACHI
Motoo SHIRO
Naoko OOGAMI
Hiroshi MIZUNO
Tsuneo NAMBA
Author's Organization：
Research Institute for Wakan-Yaku (Traditional Siro-Japanese Medicines), Toyama Medical and Pharmaceutical University
Research Institute for Wakan-Yaku (Traditional Siro-Japanese Medicines), Toyama Medical and Pharmaceutical University
Research Institute for Wakan-Yaku (Traditional Siro-Japanese Medicines), Toyama Medical and Pharmaceutical University
Research and Development Division, Rigaku Industrial Corporation
Research and Development Division, Rigaku Industrial Corporation
National Institute of Agrobiological Resources
National Institute of Agrobiological Resources
Research Institute for Wakan-Yaku (Traditional Siro-Japanese Medicines), Toyama Medical and Pharmaceutical University

Keywords: Cimicifuga heracleifolia, Ranunculaceae, cycloartane-type triterpene 24-epi-7, 8-didehydrocimigenol, 2D NMR

JOURNAL FREE ACCESS

1993 Volume 41 Issue 5 Pages 832-841

DOI https://doi.org/10.1248/cpb.41.832

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Abstract

Ten new highly oxidized cycloartane-type triterpenoids, 24-epi-7, 8-didehydrocimigenol, 7, 8-didehydrocimigenol, 25-O-acetyl-7, 8-didehydrocimigenol, 3-keto-24-epi-7, 8-didehydrocimigenol, 2', 4'-O-diacetyl-24-epi-7, 8-didehydrocimigenol-3-xyloside, 3'-O-acetyl-24-epi-7, 8-didehydrocimigenol-3-xyloside, 24-epi-7, 8-didehydrocimigenol-3-xyloside, 7, 8-didehydro-24-O-acetylhydroshengmanol-3-xyloside, 24-epi-acerinol and heracleifolinol, were isolated from the rhizome of Cimicifuga heracleifolia KOMAROV and their structures were determined by the use of two-dimensional nuclear magnetic resonance (2D NMR) techniques (¹H-¹H correlation spectroscopy (COSY), ¹H-¹³C COSY, ¹H-¹³C long-range COSY) and by X-ray diffraction analysis of the 3-keto compound.

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