Cytotoxic Sesquiterpenes from Nardostachys chinensis

Hideji ITOKAWA; Koichi MASUYAMA; Hiroshi MORITA; Koichi TAKEYA

doi:10.1248/cpb.41.1183

Hideji ITOKAWA, Koichi MASUYAMA, Hiroshi MORITA, Koichi TAKEYA

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Keywords: desoxo-narchinol-A, cytotoxic activity, Nardostachys chinensis, Valerianaceae, sesquiterpene

JOURNAL FREE ACCESS

1993 Volume 41 Issue 6 Pages 1183-1184

DOI https://doi.org/10.1248/cpb.41.1183

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Abstract

Five cytostatic sesquiterpenes, desoxo-narchinol-A (1), nardosinone (2), debilon (3), nardosinonediol (4) and kanshone A (5), were isolated from the roots and rhizomes of Nardostachys chinensis (Valerianaceae). The steric structure of 1 was determined by nuclear Overhauser effects (NOEs) and the exciton chirality method. All five showed cytotoxic activity against P-388 cells and the structure-activity relationship of 1 was also discussed.

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