SYNTHESIS OF RESTRICTINOL AND 9, 10, 11, 12-TETRAHYDRO-7-DESMETHYLRESTRICTICIN

Takuo TSUKUDA; Isao UMEDA; Kazunao MASUBUCHI; Michio SHIRAI; Nobuo SHIMMA

doi:10.1248/cpb.41.1191

Takuo TSUKUDA, Isao UMEDA, Kazunao MASUBUCHI, Michio SHIRAI, Nobuo SHIMMA

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Keywords: Restrictinol, Restricticin, 9, 10, 11, 12-tetrahydro-7-desmethylrestricticin, antifungal agent, synthesis

JOURNAL FREE ACCESS

1993 Volume 41 Issue 6 Pages 1191-1193

DOI https://doi.org/10.1248/cpb.41.1191

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Abstract

Restrictinol 2 and 9, 10, 11, 12-tetrahydro-7-desmethylrestricticin (Ro 09-1571) have been synthesized from L-glucose. Ro 09-1571 showed improved in vitro antifungal activity and chemical stability as compared with Restricticin 1.

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