PRODUCTION OF HIGHLY SPECIFIC ANTIBODIES TO 1α, 25-DIHYDROXYVITAMIN D3 UTILIZING A NOVEL HAPTENIC DERIVATIVE HAVING A CHEMICAL BRIDGE AT 11α-POSITION

Norihiro KOBAYASHI; Junichi KITAHORI; Hidetoshi MANO; Kazutake SHIMADA

doi:10.1248/cpb.41.1321

PRODUCTION OF HIGHLY SPECIFIC ANTIBODIES TO 1α, 25-DIHYDROXYVITAMIN D₃ UTILIZING A NOVEL HAPTENIC DERIVATIVE HAVING A CHEMICAL BRIDGE AT 11α-POSITION

Norihiro KOBAYASHI, Junichi KITAHORI, Hidetoshi MANO, Kazutake SHIMADA

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Keywords: 1α, 25-dihydroxyvitamin D₃, RIA, specific antibody, haptenic derivative, 11α-hemiglutaryloxy-1α, 25-dihydroxyvitamin D₃, 11α, 25-dihydroxycholesterol

JOURNAL FREE ACCESS

1993 Volume 41 Issue 7 Pages 1321-1323

DOI https://doi.org/10.1248/cpb.41.1321

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Abstract

The production of highly specific antibodies to 1α, 25-dihydroxyvitamin D₃ 1a utilizing a novel haptenic derivative 2, which was synthesized from 11_α, 25-dihydroxycholesterol via 21 steps, has been reported. The properties of the obtained antibodies are also described.

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