Structures and Solid State Tautomeric Forms of Two Novel Antileukemic Tropoloisoquinoline Alkaloids, Pareirubrines A and B, from Cissampelos pareira

Hiroshi MORITA; Kouji MATSUMOTO; Koichi TAKEYA; Hideji ITOKAWA; Yoichi IITAKA

doi:10.1248/cpb.41.1418

Hiroshi MORITA, Kouji MATSUMOTO, Koichi TAKEYA, Hideji ITOKAWA, Yoichi IITAKA

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Keywords: tropoloisoquinoline alkaloid, pareirubrine, Cissampelos pareira, Menispermaceae, antileukemic activity, X-ray analysis

JOURNAL FREE ACCESS

1993 Volume 41 Issue 8 Pages 1418-1422

DOI https://doi.org/10.1248/cpb.41.1418

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Abstract

Two novel tropoloisoquinoline alkaloids, Pareirubrines A and B, have been isolated as antileukemic substances from Cissampelos pareira(Menispermaceae), together with the same skeleton alkaloids, grandirubrine and isoimerubrine. Their structures were elucidated by nuclear magnetic resonance (NMR) studies, and their solid state tautomeric forms were examined by X-ray crystallographic analysis.

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