Synthesis of Novel Hydrophenanthrene Derivatives

Takeshi SHIMIZU; Sayoko HIRANUMA; Takahiro OKUBO; Hirosuke YOSHIOKA

doi:10.1248/cpb.41.1524

Takeshi SHIMIZU, Sayoko HIRANUMA, Takahiro OKUBO, Hirosuke YOSHIOKA

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Keywords: hydrophenanthrene, lactam, Wieland-Miescher ketone, Robinson annelation, 1-chloro-3-pentanone

JOURNAL FREE ACCESS

1993 Volume 41 Issue 9 Pages 1524-1529

DOI https://doi.org/10.1248/cpb.41.1524

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Abstract

Novel hydrophenanthrene lactams (4a, b and 13-16) and hydrophenanthrene derivatives (5a-c and 6a-d) bearing an angular carboxymethyl group were synthesized in good yield via the tricyclic compounds (3a, b) readily prepared from the cyanomethyl derivative (2) of Wieland-Miescher ketone and 1-chloro-3-pentanone.

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