Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
PH-SENSITIVE DOCOSANOIC ACID-NICOTINAMIDE COMPLEX, AND ITS APPLICABILITY TO A PH-RESPONSIVE DRUG DELIVERY SYSTEM
Shoko YOKOYAMA, Masaaki SUNOHARA, Tadao FUJIE
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Keywords: pH-sensitive complex, docosanoic acid, nicotinamide, pH-responsive release, drug delivery system
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1993 Volume 41 Issue 9 Pages 1674-1676

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Abstract
The release of nicotinamide (NAA) from docosanoic acid (C22)-NAA complex was measured in pH 1.2-6.8 aqueous media. The release of NAA was ON-state below pH 6.2 and OFF-state at pH 6.8, suggesting that the release behavior is applicable to a pH-responsive drug delivery system.
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© The Pharmaceutical Society of Japan
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