Studies of Reactive Inorganic Layered Compounds with Drugs. I. Intercalation of Phosphatidylcholine Containing Indomethacin into Synthetic Mica

Abstract

The interaction between a sodium-type synthetic mica (Na-TSM), a model material of reactive layered compounds, and phosphatidylcholine (PC) in a solid dispersion (IM-PC) with indomethacin (IM), a model drug, was investigated using X-ray diffraction analysis. It was found that IM-PC interacts with Na-TSM, and can be immobilized in the interlayer space by means of heating. When IM mole fractions in IM-PC increased from 0.25 to 0.5, the amount of IM intercalated into Na-TSM increased correspondingly from 5-18%. Consequently, it was determined that inorganic layered compounds, such as Na-TSM, intercalated with drugs in PC can be obtained.