TEMPERATURE CONTROL FOR THE DIASTEREOSELECTIVE HYDROLYSIS OF DIPEPTIDE ESTERS IN THE BUFFER SOLUTION

Ryuichi UEOKA; Yoshito MATSUMOTO; Tetsuo ITO; Yoko MATSUMOTO; Yasuo KATO

doi:10.1248/cpb.42.173

Ryuichi UEOKA, Yoshito MATSUMOTO, Tetsuo ITO, Yoko MATSUMOTO, Yasuo KATO

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Keywords: dipeptide ester, diastereoselective hydrolysis, conformational change, temperature control

JOURNAL FREE ACCESS

1994 Volume 42 Issue 1 Pages 173-175

DOI https://doi.org/10.1248/cpb.42.173

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Abstract

A remarkably high stereoselectivity was attained for the hydrolysis of dipeptide p-nitrophenyl esters (DL/LL=101 for Z-Phe-Phe-PNP and DL/LL=71 for Z-Phe-Leu-PNP) without a catalyst in pH 9.5, 0.02 M carbonate buffer at the optimum temperature (32.5°C).

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