Cardenolide Glycosides from the Roots of Apocynum cannabinum

Abstract

Steroidal constituents from the roots of Apocynum cannabinum L. were investigated. (20S)-, (20R)-18, 20-Epoxycymarin and (20S)-18, 20-epoxyapocannoside were isolated along with cannogenin, strophanthidin and cannogenol glycosides, including D-cymaroside, D-oleandroside, D-digitoxoside and D-digitaloside, and their glucosyl, cellobiosyl or gentiobiosyl glycosides. Two pregnanes, neridienone A and 6, 7-didehydrocortexone, were obtained, accompanied with cardenolides.