Synthesis of Fluorine Analogs of Vitamin E. III. Synthesis of 2-[4, 8-Dimethyl-12-(trifluoromethyl)tridecyl]-2, 5, 7, 8-tetramethyl-6-chromanol and 2-[4, 12-Dimethyl-8-(trifluoromethyl)tridecyl]-2, 5, 7, 8-tetramethyl-6-chromanol

Mayumi KOYAMA; Mihoko TAMURA; Akira ANDO; Itsumaro KUMADAKI

doi:10.1248/cpb.42.2154

Mayumi KOYAMA, Mihoko TAMURA, Akira ANDO, Itsumaro KUMADAKI

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Keywords: vitamin E, tocopherol, trifluoromethyl, Wittig reaction, trifluoromethyl ketone, 6-chromanol

JOURNAL FREE ACCESS

1994 Volume 42 Issue 10 Pages 2154-2156

DOI https://doi.org/10.1248/cpb.42.2154

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Abstract

2-[4, 8-Dimethyl-12-(trifluoromethyl)tridecyl]-2, 5, 7, 8-tetramethyl-6-chromanol and 2-[4, 12-dimethyl-8-(trifluoromethyl)tridecyl]-2, 5, 7, 8-tetramethyl-6-chromanol, were synthesized by means of the Wittig reaction using the phosphonium salt of 2-(3-chloropropyl)-2, 5, 7, 8-tetramethyl-6-chromanol.

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