Modeling Drug Release from Granules Coated with an Aqueous-Based System of Acrylate Methacrylate : Effect of Moisture Content on the Kinetics of Drug Release

Abstract

A simple model, which can be used to analyze data of the controlled release of a water-soluble drug from spherical particles coated with an aqueous-based system of acrylate methacrylate by a tumbling fluidized bed process, is presented. This model predicts that the fractional release of a drug is related to the exponential of release time. Drug release data of several samples prepared by various levels of operational moisture content were studied by the analytical equations, and the effect of operational moisture content on fil thickness and permeability of a drug were investigated. It was found that the experimental results were very well represented by the analytical equations, and the mechanism of an aqueous coating was elucidated.