Synthesis and Biological Activity of the Metabolites of syn-3-Ethyl-7-methyl-3, 7-diazabicyclo[3.3.1]non-9-yl 4-Chlorobenzoate Hydrochloride

Ichiro YAMAWAKI; Scott W. BUKOVAC; Akihiko SUNAMI

doi:10.1248/cpb.42.2365

Ichiro YAMAWAKI, Scott W. BUKOVAC, Akihiko SUNAMI

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Keywords: metabolite, anti-arrhythmic agent, sodium current blocking activity, syn-3-ethyl-7-methyl-3, 7-diazabicyclo[3.3.1]non-9-yl 4-chlorobenzoate

JOURNAL FREE ACCESS

1994 Volume 42 Issue 11 Pages 2365-2369

DOI https://doi.org/10.1248/cpb.42.2365

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Abstract

Five metabolites of syn-3-ethyl-7-methyl-3, 7-diazabicyclo[3.3.1]non-9-yl 4-chlorobenzoate hydrochloride (YUTAC)(1) were prepared and examined for Na⁺ current blocking activity in guinea pig ventricular myocytes. These metabolites showed lower inhibitory activities than the parent compound or were inactive.

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