SYNTHETIC STUDY OF MARINE MACROLIDE SWINHOLIDE A. STEREOCONTROLLED SYNTHESIS OF THE C11-C32 SEGMENT

Tadashi NAKATA; Toshiya KOMATSU; Kazuo NAGASAWA

doi:10.1248/cpb.42.2403

Tadashi NAKATA, Toshiya KOMATSU, Kazuo NAGASAWA

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Keywords: swinholide A, stereocontrolled synthesis, C11-C32 segment, 1, 3-polyol, aldol condensation

JOURNAL FREE ACCESS

1994 Volume 42 Issue 11 Pages 2403-2405

DOI https://doi.org/10.1248/cpb.42.2403

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Abstract

The C24-C32 segment 4 of swinholide A (1) was stereoselectively synthesized starting from (S)-methyl 3-hydroxybutyrate, and the convergent synthesis of the C11-C32 segment 5 was accomplished via stereoselective aldol condensation of 3 and 4

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