1994 年 42 巻 12 号 p. 2514-2517
Sodium chimaerol sulfate (1) was isolated from the bile of Lamna ditropis and Rhizoprionodon acutus by chromatography on silica gel and Sephadex LH-20, together with sodium scymnol sulfates, (24R, 25S)- and (24R, 25R)-(+)-3α, 7α, 12α, 24, 26-pentahydroxy-5β-cholestan-27-yl sodium sulfates (3 and 4) and 3, respectively. On acid hydrolysis, compound 1 afforded chimaerol (2), which was identified as (24R, 25R)-(+)-5β-cholestane-3α, 7α, 12α, 24, 26-pentol by direct comparison with an authentic sample, prepared by reduction of (24R, 25S)-(+)-24, 26-epoxy-5β-cholestane-3α, 7α, 12α, 27-tetrol (5) with LiAlH4. The structure of 1 was concluded to the (24R, 25R)-(+)-3α, 7α, 12α, 24-tetrahydroxy-5β-cholestan-26-yl sodium sulfate, based on the chemical transformation and spectral data.
